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Abstract #3896

Cardiac Cine MRI for Mice with Myocardial Infarction using 3D Self-gated Radial Gradient Echo

Naoharu Kobayashi 1 , Qiang Xiong 2 , Jing Guo 2 , Jianyi Zhang 2 , and Michael Garwood 1

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, United States, 2 Department of Medicine, University of Minnesota Medical School, Minnesota, United States

A radial gradient echo sequence with cardiac self-gating is introduced for 3D cine imaging of mice with myocardial infarction (MI). Accuracy of the MR self-gating was validated by comparing with ECG signals. In order to accelerate 3D acquisition, compressed sensing reconstruction was applied and predominantly removed undersampling artifacts and noise, resulting in reasonable scan time in animal experiments (14 min). The proposed methods visualized dynamics of cardiac function for MI mice with various infarct sizes; the 3D self-gated cine MRI technique is robust for MI mice with severe arrhythmia associated with significantly adverse left ventricular remodeling.

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