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Abstract #3890

Characterization of Cardiac Function in Nave Non-Human Primates Using Strain and Flow Based MRI Biomarkers: A Test-Retest Reproducibility and Inter-Animal Variability Study

Smita Sampath 1 , Michael Klimas 2 , Richard Baumgartner 3 , Dai Feng 3 , Elaine Manigbas 4 , Ai-Leng Liang 1 , Brian Henry 1 , Jeffrey L Evelhoch 2 , and Chih-Liang Chin 1

1 Translational Medicine Research Center, Merck Sharp and Dohme, Singapore, Singapore, Singapore, 2 Imaging, Merck & Co. Inc., West Point, Pennsylvania, United States, 3 Biometric Research, Biostatistics and Research Decision Sciences, Merck & Co. Inc., Rahway, New Jersey, United States, 4 Imaging, Maccine Pte. Ltd., Singapore, Singapore

Translational pre-clinical non-human primate (NHP) models offer a unique framework to evaluate novel therapeutics for human diseases. Herein, we characterize cardiac function in NHPs using optimized MR tagging and phase-contrast imaging on a 3T MRI scanner. Our results describe regional strain and flow characteristics and their temporal relationships during systolic pumping and diastolic filling. We also demonstrate good intra-subject reproducibility and acceptable inter-subject variability in quantitative strain and flow based imaging biomarkers. Prospective power analyses support the future application of these non-invasive functional biomarkers to evaluate longitudinal changes in cardiac function during drug safety or efficacy studies of experimental compounds.

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