Abstract #3885
Tissue Phase Mapping analysis of IKr-blocker E4031 effects on mechanical cardiac function in transgenic long-QT syndrome type 1 rabbits
Marius Menza 1 , David Ziupa 2 , Julia Beck 2 , Gerlind Franke 2 , Stefanie Perez Feliz 2 , Michael Brunner 2 , Gideon Koren 3 , Manfred Zehender 2 , Daniela Fll 2 , Bernd A. Jung 1 , and Katja E. Odening 2
1
Department of Radiology - Medical Physics,
University Medical Center, Freiburg, Germany,
2
Department
of Cardiology and Angiology I, University Medical
Center, Freiburg, Germany,
3
Cardiovascular
Research Center, Division of Cardiology, Rhode Island
Hospital, Alpert Medical School of Brown University,
Providence, RI, United States
A variety of different drugs block cardiac IKr-currents
thus causing a serious side effect, the so called
acquired Long-QT syndrome with a prolongation of cardiac
repolarization (prolonged QT interval) and sudden
cardiac death. Using Tissue Phase Mapping, we
investigated the influence of IKr-blocking drug E4031 on
global and segmental mechanical cardiac function in
transgenic LQT type 1 rabbits (loss of IKs, with a
particularly high susceptibility to IKr-blocking drugs)
and wild-type littermate controls.
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