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Abstract #3885

Tissue Phase Mapping analysis of IKr-blocker E4031 effects on mechanical cardiac function in transgenic long-QT syndrome type 1 rabbits

Marius Menza 1 , David Ziupa 2 , Julia Beck 2 , Gerlind Franke 2 , Stefanie Perez Feliz 2 , Michael Brunner 2 , Gideon Koren 3 , Manfred Zehender 2 , Daniela Fll 2 , Bernd A. Jung 1 , and Katja E. Odening 2

1 Department of Radiology - Medical Physics, University Medical Center, Freiburg, Germany, 2 Department of Cardiology and Angiology I, University Medical Center, Freiburg, Germany, 3 Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States

A variety of different drugs block cardiac IKr-currents thus causing a serious side effect, the so called acquired Long-QT syndrome with a prolongation of cardiac repolarization (prolonged QT interval) and sudden cardiac death. Using Tissue Phase Mapping, we investigated the influence of IKr-blocking drug E4031 on global and segmental mechanical cardiac function in transgenic LQT type 1 rabbits (loss of IKs, with a particularly high susceptibility to IKr-blocking drugs) and wild-type littermate controls.

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