Abstract #3847
Impaired venous return due to right ventricular diastolic stiffness in Pulmonary Arterial Hypertension
J. Tim Marcus 1 , Marielle van de Veerdonk 2 , Frank Oosterveer 3 , Rudolf Verdaasdonk 1 , and Anton Vonk Noordegraaf 2
1
Physics & Medical Technology, VU University
Medical Center, Amsterdam, Netherlands,
2
Pulmonology,
VU University Medical Center, Netherlands,
3
VU
University Medical Center, Netherlands
The aim was to explore the association between Vena Cava
(VC) backflow and right ventricular (RV) diastolic
stiffness in pulmonary arterial hypertension (PAH). In
35 PAH patients, VC flow was measured by MRI velocity
quantification, and right heart pressures by
catheterization. The VC backflow fraction was related to
the right atrium maximal pressure (p<0.00001, r2=0.53),
and to RV diastolic stiffness (p<0.00001, r2=0.53). This
explains the impact of RV diastolic dysfunction on right
atrial pressure and subsequently on the venous return in
PAH.
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