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Abstract #3807

Carnitine supplementation creates a cardiac reserve of free carnitine to enable buffering of excess acetyl units

Michael S Dodd 1 , Andrew J Lewis 1 , Vicky Ball 1 , and Damain J Tyler 1

1 Oxford Metabolic Imaging Group, University of Oxford, Oxford, OXON, United Kingdom

Carnitine performs several vital roles in cellular metabolism including facilitating the transport of fatty acids into the mitochondria and buffering acetyl groups from excess acetyl-CoA. Carnitine supplementation has been proposed as a treatment for conditions such as heart failure. In this study, short-term carnitine supplementation in control animals did not alter the metabolism of pyruvate under normal situations. However, during a time of increased acetyl group availability, caused by dichloroacetate infusion, there was evidence of a carnitine reserve which was able to buffer excess acetyl groups into acetylcarnitine, allowing recycling of CoA back into β-oxidation or the TCA cycle.

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