Abstract #3801
Measuring polarization using asymmetry of hyperpolarized [1,2- 13 C]Pyr doublets
Keshav Datta 1 , Sonal Josan 2 , and Daniel Spielman 2
1
Dept. of Electrical Engineering, Stanford
University, Stanford, CA, United States,
2
Department
of Radiology, Stanford University, Stanford, CA, United
States
Knowledge of the liquid-state polarization is necessary
for absolute quantitation of in vivo hyperpolarized MRS
data. In contrast to earlier work suggesting asymmetry
of the C2 doublet (aC2) of [1,2-13C]Pyr (1% naturally
abundant in a hyperpolarized [1-13C]Pyr sample) can
directly be used to compute the instantaneous
polarization, we present both analytic expressions and
experimental results demonstrating a single measurement
of aC2 is insufficient, and polarization calculations
also depend on both the delay between the sample exiting
the polarizer and the time of measurement as well as
knowledge of the T1 decay rates of the individual peaks
in the doublet resonance.
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