Abstract #3787
Associations of glutamate, membrane phospholipid and high energy metabolism a combined 1 H- and 31 P-MR spectroscopic imaging study
Alexander Gussew 1 , Stefan Smesny 2 , Reinhard Rzanny 1 , Patrick Hiepe 1 , and Jrgen R. Reichenbach 1
1
Medical Physics Group, Department of
Diagnostic and Interventional Radiology I, Jena
University Hospital, Jena, Thuringia, Germany,
2
Department
of Psychiatry and Psychotherapy, Jena University
Hospital, Jena, Thuringia, Germany
This study combined
1
H-
and
31
P-MR
brain spectroscopy to assess the associations between
the neurotransmitter glutamate, the membrane
phospholipid precursors (PME) and breakdown products
(PDE) and the energy turnover markers (PCr) in healthy
subjects. Significant positive correlations were
observed between glutamate and PDE (rho>0.3), indicating
for the glutamatergic modulation of membrane
phospholipid breakdown. Furthermore, PDE increased with
decreasing PCr (rho < -0.25), indicating increased
energy demand to compensate the increased membrane
turnover.
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