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Abstract #3763

In Vivo 17 O MR Imaging and Quantification of CMRO 2 , CBF and OEF in Human Visual Cortex at Rest and during Activation

Xiao-Hong Zhu 1 , Xiao Liu 1 , Ming Lu 1 , Hannes M Wiesner 1 , Kamil Ugurbil 1 , and Wei Chen 1

1 CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States

In vivo 17 O MRS/I technique has unique ability for assessing oxygen metabolism via 17 O-labeled oxygen gas inhalation. However, quantification of cerebral metabolic rate of oxygen (CMRO 2 ) in human is complicated by the large body size and slow gas exchange process, which becomes more problematic when a short inhalation is applied. In this study, a simple approach was proposed for measuring the gas exchange rate in the lung, which was incorporated into a comprehensive quantification model for simultaneous determination of three important physiology parameters of CMRO 2 , CBF and OEF in the human brain. This new approach was tested in resting and stimulated human brain. The preliminary results showed similar resting state CMRO 2 , CBF and OEF values as reported in literature; and a large CBF increase (>40%) in accompany with smaller increases in CMRO 2 and OEF (<20%) were observed in activated visual cortex, which support the notion of unmatched CMRO 2 and CBF changes in response to a physiological stimulation. The overall results validate the proposed model and provide a quantitative neuroimaging tool for noninvasive imaging CMRO 2 , CBF and OEF in healthy and diseased human brains.

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