Abstract #3763
In Vivo 17 O MR Imaging and Quantification of CMRO 2 , CBF and OEF in Human Visual Cortex at Rest and during Activation
Xiao-Hong Zhu 1 , Xiao Liu 1 , Ming Lu 1 , Hannes M Wiesner 1 , Kamil Ugurbil 1 , and Wei Chen 1
1
CMRR, Department of Radiology, University of
Minnesota Medical School, Minneapolis, MN, United States
In vivo
17
O
MRS/I technique has unique ability for assessing oxygen
metabolism via
17
O-labeled
oxygen gas inhalation. However, quantification of
cerebral metabolic rate of oxygen (CMRO
2
) in
human is complicated by the large body size and slow gas
exchange process, which becomes more problematic when a
short inhalation is applied. In this study, a simple
approach was proposed for measuring the gas exchange
rate in the lung, which was incorporated into a
comprehensive quantification model for simultaneous
determination of three important physiology parameters
of CMRO
2
, CBF and OEF in the human brain.
This new approach was tested in resting and stimulated
human brain. The preliminary results showed similar
resting state CMRO
2
, CBF and OEF values as
reported in literature; and a large CBF increase (>40%)
in accompany with smaller increases in CMRO
2
and
OEF (<20%) were observed in activated visual cortex,
which support the notion of unmatched CMRO
2
and
CBF changes in response to a physiological stimulation.
The overall results validate the proposed model and
provide a quantitative neuroimaging tool for noninvasive
imaging CMRO
2
, CBF and OEF in healthy and
diseased human brains.
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