Metabonomics of Celiac Disease by in-vitro Proton NMR Spectroscopy of Blood Plasma
Deepti Upadhyay 1 , Naranamangalam R Jagannathan 1 , Uma Sharma 1 , Govind Makharia 2 , Prasenjit Das 3 , and Siddhartha Datta Gupta 3
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
of Gastroeneterology, All India Institute of Medical
Sciences, New Delhi, Delhi, India,
of Pathology, All India Institute of Medical Sciences,
New Delhi, Delhi, India
Celiac disease (CeD) is an autoimmune enteropathy caused
by ingestion of gluten and related prolamines present in
cereals like wheat, rye, and barley in genetically
predisposed individuals. Proton NMR based metabonomics
of blood plasma of CeD patients showed higher
concentration of glucose, acetoacetate, alanine and
glycine compared to controls which may be due to
alteration in energy metabolism. Blood plasma of CeD
patients were also characterized by higher level of
glutamine suggesting its involvement in pathogenesis.
Decreased concentration of creatinine is observed in
blood plasma of CeD patients in comparison to controls.
This may be due to protein malabsorption.
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