Abstract #3754
First HR-MAS MRS Slice-Localized Spectroscopy (S.L.S.) and (frequency/space) C.S.I. of living drosophila.
Nicolas Joudiou 1 , Fanny Louat 1 , Sandra Mme 1 , Martine Decoville 1 , Vincent Sarou-Kanian 2 , and Jean-Claude Beloeil 1
1
CNRS CBM UPR4301, Orlans, France,
2
CNRS
CEMHTI UPR3079, Orlans, France
In addition to the models developed in monkeys and
rodents, many human diseases have been successfully
modeled in an insect, Drosophila. The aim of our work
was to develop very effective non-invasive methods for
in vivo study of Drosophila models of neurodegenerative
diseases, at metabolome level, such as HR-MAS MRS. We
have shown that it is possible to obtain semi-localized
MRS spectra (head, thorax, abdomen) of alive drosophilae
by using HR-MAS technique associated with rotating
magnetic field gradients and very high magnetic field
(17.6T). Applications to the study of mutants up101 will
be shown. Studies on neurodegenerative flies models are
ongoing.
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