Abstract #3744
Improved off-resonance phase behavior using a phase-inverted adiabatic half passage pulse for 13 C MRS in humans at 7T
Eulalia Sers Roig 1 , Lijing Xin 2 , Daniel Gallichan 3 , Vladimir Mlynarik 3 , and Rolf Gruetter 1,4
1
Laboratory of Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne (EPFL), Lausanne, Vaud, Switzerland,
2
Unit
for Research in Schizophrenia, Center for Psychiatric
Neuroscience, Department of Psychiatry, Lausanne
University Hospital (CHUV), Vaud, Switzerland,
3
Centre
d'Imagerie Biomdicale - Animal and Imaging Technology (CIBM-AIT),
Lausanne, Switzerland,
4
Department
of Radiology, Universities of Lausanne (UNIL) and Geneva
(UNIGE), Vaud, Switzerland
One of the unique features of direct 13C-MRS is its
large spectral width, allowing the detection of several
resolved carbon signals. In vivo 13C MRS is currently
performed using an adiabatic half passage (AHP) pulse
for 13C excitation. However, the excitation bandwidth of
AHP pulse is asymmetric relative to the carrier
frequency, leading to an asymmetric excitation of the
spectral lines off-resonance. In this study, we combine
two phase-inverted AHP pulses in alternate scans for 13C
excitation. We demonstrate a symmetric excitation
bandwidth and a flatter phase-response to off-resonance
by measuring 13C signals in vivo in human muscle at 7T.
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