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Abstract #3744

Improved off-resonance phase behavior using a phase-inverted adiabatic half passage pulse for 13 C MRS in humans at 7T

Eulalia Sers Roig 1 , Lijing Xin 2 , Daniel Gallichan 3 , Vladimir Mlynarik 3 , and Rolf Gruetter 1,4

1 Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland, 2 Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Vaud, Switzerland, 3 Centre d'Imagerie Biomdicale - Animal and Imaging Technology (CIBM-AIT), Lausanne, Switzerland, 4 Department of Radiology, Universities of Lausanne (UNIL) and Geneva (UNIGE), Vaud, Switzerland

One of the unique features of direct 13C-MRS is its large spectral width, allowing the detection of several resolved carbon signals. In vivo 13C MRS is currently performed using an adiabatic half passage (AHP) pulse for 13C excitation. However, the excitation bandwidth of AHP pulse is asymmetric relative to the carrier frequency, leading to an asymmetric excitation of the spectral lines off-resonance. In this study, we combine two phase-inverted AHP pulses in alternate scans for 13C excitation. We demonstrate a symmetric excitation bandwidth and a flatter phase-response to off-resonance by measuring 13C signals in vivo in human muscle at 7T.

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