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Abstract #3742

A Proof-of-Concept Study Towards in vivo Triglyceride Composition Determination by MR Spectroscopy at 3T, with Validation Against High-Resolution NMR

Takeshi Yokoo 1,2 , Qing Yuan 1 , Hongyue Yu 1 , and Robert E Lenkinski 1,2

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

The importance of the fatty acid (FA) composition in triglycerides (TG) is increasingly recognized in many pathologic processes such as cancer. Proton spectra of TGs have multiple peaks of different frequencies, whose relative peak sizes reflect the FA composition. In this proof of concept study, we selected 6 different natural TGs of different FA composition, and compared the single-voxel proton MR spectroscopy acquired from a 3T clinical scanner (128 MHz) against 400 MHz high-resolution NMR and reported values by US Department of Agriculture (USDA). We showed that estimated TG composition at 3T is highly correlated to that by high-resolution NMR, and similar to reported values by USDA. We conclude that in vivo TG composition determination may be possible clinically using 3T MRS.

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