Abstract #3742
A Proof-of-Concept Study Towards in vivo Triglyceride Composition Determination by MR Spectroscopy at 3T, with Validation Against High-Resolution NMR
Takeshi Yokoo 1,2 , Qing Yuan 1 , Hongyue Yu 1 , and Robert E Lenkinski 1,2
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States
The importance of the fatty acid (FA) composition in
triglycerides (TG) is increasingly recognized in many
pathologic processes such as cancer. Proton spectra of
TGs have multiple peaks of different frequencies, whose
relative peak sizes reflect the FA composition. In this
proof of concept study, we selected 6 different natural
TGs of different FA composition, and compared the
single-voxel proton MR spectroscopy acquired from a 3T
clinical scanner (128 MHz) against 400 MHz
high-resolution NMR and reported values by US Department
of Agriculture (USDA). We showed that estimated TG
composition at 3T is highly correlated to that by
high-resolution NMR, and similar to reported values by
USDA. We conclude that in vivo TG composition
determination may be possible clinically using 3T MRS.
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