Meeting Banner
Abstract #3725

Multi-vendor GABA-edited MRS

Richard Edden 1,2 , Ashley D Harris 1,2 , Nicolaas AJ Puts 1,2 , C John Evans 3 , Laura M Rowland 4 , S Andrea Wijtenburg 4 , and Peter B Barker 1,2

1 Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2 F.M. Kirby Research Centre, Kennedy Krieger Institute, Baltimore, MD, United States, 3 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 4 Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, United States

Edited MRS of GABA, the main inhibitory neurotransmitter in the human brain, is increasingly applied in studies of normal brain function and disease. In vivo quantification of GABA is usually achieved either by a simple integral ratio to Creatine or in institutional units, neither of which allow the comparison of quantitative data from different studies. Herein, we quantify the editing efficiency of GABA and co-editing ratio of macromolecular signal for GABA-edited sequences on GE, Philips and Siemens scanners and demonstrate in vivo that correcting for these sequence-differences significantly improves agreement between concentration measures from each vendor.

This abstract and the presentation materials are available to members only; a login is required.

Join Here