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Abstract #3698

Multinuclear ( 19 F + 1 H) high-resolution intravascular MRI of perfluorooctyl bromide (PFOB) microcapsules at 3T

Shashank Sathyanarayana Hegde 1 , Li Pan 2 , Guan Wang 1,3 , Yingli Fu 1 , and Dara Kraitchman 1

1 Radiology, Johns Hopkins University, Baltimore, Maryland, United States, 2 Siemens Corporation, Baltimore, Maryland, United States, 3 Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland, United States

Fluorine ( 19 F) MRI combined with anatomic proton ( 1 H) MRI provides an effective method for in vivo cell tracking. Recently, 3T intravascular MRI (IVMRI) probes have been shown to provide high-resolution (sub-mm) in vivo imaging capabilities with local signal-to-noise ratios superior to conventional surface coils. Here, for the first time, using a 3T IVMRI probe designed for both 1 H and 19 F MRI, we show high-resolution (in-plane: 0.2mm 1 H, 0.8mm 19 F) localization of perfluorooctyl bromide (PFOB) microcapsules in a porcine heart ex vivo . Localization is confirmed by CT imaging of the radio-opaque microcapsules.

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