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Abstract #3688

Improved survival in a metastatic brain tumour model with combined focused ultrasound and targeted natural killer cells

Ryan Alkins 1,2 , Alison Burgess 1 , Milan Ganguly 1 , Giulio Francia 1 , Robert Kerbel 1,2 , Winfried S Wels 3 , and Kullervo Hynynen 1,2

1 Sunnybrook Research Institute, Toronto, ON, Canada, 2 University of Toronto, Toronto, ON, Canada, 3 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany

Systemic treatments for breast cancer have limited success treating brain metastasis due to the blood-brain barrier (BBB). Here, we investigate the effects of repeated delivery of targeted NK-92 cells to brain metastases using MRI-guided focused ultrasound (MRIgFUS). Our data demonstrate that MRIgFUS enhances NK-92 cell translocation across the BBB. Repeated MRIgFUS and NK-92 cell treatments lead to reductions in tumour progression over time, particularly when the treatments are applied early during tumour growth. These data support the continued investigation of MRIgFUS-mediated cell delivery as a potential treatment option for metastatic brain tumours.

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