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Abstract #3635

Changes in Choline Level and Lipid Profile in Rat Liver During Lipid Infusion Measured by Dynamic Proton MRS

Peng Cao 1,2 , Shu-Juan J. FAN 1,2 , Anna M. Wang 1,2 , Victor B. Xie 1,2 , Iris Y. Zhou 1,2 , and Ed X. Wu 1,2

1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong SAR, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong SAR, China

The liver proton MR spectroscopy (MRS) is typically used for quantifying lipid content. Previous proton MRS studies have reported the quantifications of liver lipid profile and liver choline in vivo. This study aimed to examine whether dynamic proton MRS can assess the time courses of liver choline level and lipid profile in response to the acute lipid intake. Our preliminary results suggested that dynamic proton MRS could measure the changes of choline level and lipid profile in normal rat liver with acute intravenous lipid infusion.

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