Abstract #3613
Diffusion-weighted imaging detects early progression of renal fibrosis in a murine model of unilateral ureteral obstruction
Guihua Zhai 1 , Guihua Zhai 1 , Bo Chen 1 , Hyunki Kim 1 , Kurt Zinn 1 , and Anupam Agarwal 1
1
University of Alabama at Birmingham,
Birmingham, AL, United States
The purpose of this study was to confirm that apparent
diffusion coefficient (ADC) is a reliable biomarker for
the assessment of renal fibrosis in a murine model of
unilateral ureteral obstruction (UUO). On day 0, group 1
had surgery for UUO, while group 2 was used as a sham
group (only incision was applied). ADC and volume of
kidneys were measured on days 1, 3 and 7. Relative ADC
(ADC of ipsilateral side divided by ADC of contralateral
side) of parenchyma differed significantly on days 3 and
7 between UUO group and control group. Our results
suggest the relative ADC may serve as a reliable imaging
biomarker.
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