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Abstract #3610

Hypoxia accelerated metabolic alterations in the diabetic kidney assessed with hyperpolarized MRS

Christoffer Laustsen 1,2 , Sara Lycke 3 , Fredrik Palm 3,4 , Jakob Appel stergaard 5,6 , Bo Martin Bibby 7 , Rikke Nrregaard 8 , Allan Flyvbjerg 5 , Michael Pedersen 1 , and Jan Henrik Ardenkjaer-larsen 9,10

1 MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Aarhus, Denmark, 2 bDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 3 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden, 4 Division of Drug Research, Department of Medical and Health Sciences, Linkping University, Linkping, Sweden, 5 Department of Endocrinology and Internal Medicine, Aarhus University, Aarhus, Denmark, 6 The Danish Diabetes Academy, Aarhus, Denmark, 7 Department of Biostatistics, Aarhus University, Aarhus, Denmark, 8 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 9 GE Healthcare, Broendby, Denmark, 10 Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark

We demonstrated an increased oxygen sensitivity in kidneys of diabetic patients, using hyperpolarized [1- 13 C]pyruvate and BOLD MRI. This finding may explain the observed increased risk of developing nephropathy in diabetic patients inspiring reduced oxygen (<20%). The underlying explanation is likely explained by an acceleration of the hyperglycemia mediated polyol pathway cascade, leading to an overproduction of nicotinamide adenine dinucleotide (NADH), thereby increasing the lactate pool, while the oxidative phosphorylation is unaffected. In parallel, we observed a correlation between the [1- 13 C]pyruvate derivates: alanine and bicarbonate; which may potentially be used as a sensitive marker for intrarenal oxygen deficiency.

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