Abstract #3558
Effect of Iodinated Contrast Medium in Diabetic Rat Kidney as Evaluated by BOLD MRI
Lu-Ping Li 1,2 , Tammy Franklin 1 , Richard Solomon 3 , and Pottumarthi V Prasad 1,2
1
Radiology, Northshore University
HealthSystem, Evanston, IL, United States,
2
University
of Chicago Pritzker School of Medicine, Chicago, IL,
United States,
3
University
of Vermont College of Medicine, VT, United States
Iodinated contrast induced acute kidney injury (CIAKI)
is the third cause of hospital-acquired AKI. Diabetes is
one direct risk factor. Streptozotocin (STZ) treated rat
is the most common model of human diabetes. The effects
of iodinated contrast were evaluated in STZ treated rats
using BOLD MRI. Our preliminary data show R2* responses
are much smaller than those previously observed in
alternate model of CIAKI. This is probably due to the
persistent hyperfiltration in this model resulting in
enhanced washout of contrast medium. Future studies may
be necessary to evaluate whether fluid restriction could
make the responses comparable to previous models.
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