Abstract #3532
SPECTROSCOPY OF DISSOLVED 129 Xe IN HUMAN BRAIN AT 1.5T
Madhwesha Rama Rao 1 , Neil J Stewart 1 , Graham Norquay 1 , and Jim M Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom
Hyperpolarized 129Xe has large range of chemical shift
and can be used to study the human brain when 129Xe
dissolved in the blood is transferred to white matter,
grey matter and cerebral lipids. In this work we
demonstrate in vivo human brain spectroscopy with
dissolved 129Xe at 1.5T. In addition to peaks from grey
and white matter, we detected peaks from 129Xe in red
blood cells and lipids in the brain. We have established
optimal topology for RF coils for 129Xe brain
spectroscopy and developed a model for dissolved xenon
blood uptake from the lungs to the brain.
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