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Abstract #3523

A Comparison Study of Imaging CBF Change in Transient MCAO Rat Brain with the SR-T 1 Method and the CASL Technique

Xiao Wang 1 , Afshin A Divani 2 , Yi Zhang 1 , Wei Chen 1 , and Xiao-Hong Zhu 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States, 2 Neurology, University of Minnesota, Minnesota, United States

The SR-T1 method of imaging CBF change has previously validated with the Laser Doppler flowmetry measurement, the continuous arterial spin labeling (CASL) technique and at different field strength in either normal or global four-vessel occlusion rat model. In the present study, the SR-T1 method is further verified with the CASL technique in the preclinical unilateral MCAO rat brain. The results reveal that both the SR-T1 method and the CASL technique are sensitive to the impaired vascular response subsequent to the ischemic attack induced by MCA occlusion. There is an excellent agreement of the CBF change values in different ROIs and spatial pattern in the delta CBF images measured with the SR-T1 method and the CASL technique. Therefore, the SR-T1 method provides a robust, noninvasive and reliable tool to image CBF change in an absolute scale induced by physiological and pathological conditions associated with cerebrovascular diseases.

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