Abstract #3514
Correlation of quantitative MRI and histology of surgical specimens in drug-resistant focal epilepsy
Maged Goubran 1 , Robert R. Hammond 2 , Sandrine de Ribaupierre 3 , Terry M. Peters 1 , and Ali R. Khan 1
1
Imaging Laboratories, Robarts Research
Institute, London, Ontario, Canada,
2
Department
of Pathology, Western university, London, Ontario,
Canada,
3
Department of Clinical Neurological
Sciences, Western university, London, Ontario, Canada
The pathological basis of abnormal MRI signals is poorly
understood in focal epilepsy and correlation between
histology and pre-operative MRI is needed. Our objective
is to correlate quantitative in-vivo MR sequences and
histology of surgical specimens from drug-resistant
temporal lobe epilepsy patients. This study is the first
to assess the relation between MRI and histology using
correspondences based on image registration. By means of
quantitative MRI metrics and histological features we
demonstrated a significant correlation between T1 values
and neuronal density in the grey matter. This
correlation could subsequently allow prediction of
pathology from in-vivo imaging.
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