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Abstract #3495

Abnormalities in brain structure and biochemistry associated with mdx mice measured by in vivo MRI and high resolution localized 1 H MRS

Su Xu 1 , Da Shi 1 , Stephen JP Pratt 2 , Wenjun Zhu 1 , Andrew Marshall 1 , and Richard M Lovering 2

1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, United States

Duchenne muscular dystrophy (DMD) is an X-linked disorder characterized by progressive wasting of skeletal muscles and, in some patients, cognitive impairment. DMD is caused by the lack of dystrophin. To date the knowledge about dystrophin function is derived from studies of dystrophin-deficient animals, with the most common model being the mdx mouse. We studied the brains of one-year-old mdx mice in vivo and report enlarged lateral ventricles and elevations in glutathione and taurine in the hippocampus. Such findings indicate a structural change, an altered cellular antioxidant defenses and a perturbed osmoregulation in the brain due to the lack of dystrophin.

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