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Abstract #3476

Age Dependence of Brain Bioenergetics in Bipolar Disorder

Jonathan Dudley 1,2 , James Eliassen 1,2 , Elizabeth Fugate 2 , Wen-Jang Chu 1,2 , and Jing-Huei Lee 1,2

1 Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States, 2 Center for Imaging Research, University of Cincinnati, Cincinnati, Ohio, United States

The gray mater (GM) bioenergentic metabolisms in patients with bipolar disoder (BD) were investigated. Tissue regression analysis of 31P MRSI data was performed based on tissue contents that were obtained by SPM5 segmentation of MDEFT images. The results showed that dependence on age was significantly different in GM between BD and healthy control groups for concentrations of inorganic phosphate (p = 0.0032), phosphocreatine (p = 0.0029), and adenosine triphosphate (p = 0.0176). This implies that neuronal bioenergetic abnormality increases in severity with duration of illness.

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