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Abstract #3454

Functional-structural relationship in the cervical spinal cord: application to multiple sclerosis

Moreno Pasin 1 , Marios Yiannakas 1 , Hugh Kearney 1 , Ahmed Toosy 2 , and Claudia A. M. Wheeler-Kingshott 1

1 NMR Unit, Department of Neuroinflammation, UCL, Institute of Neurology, London, United Kingdom, 2 Department of Brain Repair and Rehabilitation, UCL, Institute of Neurology, London, United Kingdom

We investigated correlations between functional and diffusion data in the spinal cord in patients affected by Multiple Sclerosis. Four healthy controls and four MS patients participated in this study. Sensory stimulus was applied and activations were found in all subjects. Greater lateralization index (LI) in MS patients was significantly associated with lower posterior column white matter fractional anisotropy (PCWM-FA) and higher EDSS. Controls did not show a significant relation between LI and PCWM-FA. PCWM-FA showed less variance in controls than MS patients. This pilot study reports significant correlations between fMRI and diffusion data, albeit with small sample sizes.

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