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Abstract #3434

Brain Changes on DTI and ASL in patient with vitamin B12 deficiency while on therapy

Bhaswati Roy 1 , Rakesh K Gupta 1 , Pradeep Kumar Gupta 2 , Ravindra Kumar Garg 2 , Yogita Rai 3 , Hardeep Singh Malhotra 2 , and Chandra M Pandey 4

1 Radiology & Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana, India, 2 Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India, 3 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 4 Biostatistics & Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

To evaluate brain changes on DTI and ASL in patient with vitamin B12 deficiency while on therapy, 16 patients(baseline and after 2-months therapy) and 16 age-and-sex matched controls were enrolled. Voxel-wise analysis and TBSS analysis were performed for comparing pre-and post-therapy changes in CBF and FA values respectively. Significant increase in CBF in GM and significant decrease in WM after therapy was observed however pre-and post-therapy FA changes were not significant. Alteration in the CBF values following treatment with no significant changes in the FA values suggest that CBF change may be an early predictor of recovery than FA.

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