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Abstract #3420

Dynamic evolution of atrophy after traumatic brain injury

Christian Ledig 1 , Virginia Newcombe 2 , Guy Williams 3 , Joanne Outtrim 2 , Anne Manktelow 2 , Peter Hutchinson 4 , Jonathan Coles 2 , Daniel Rueckert 5 , and David Menon 2

1 Department of Computing, Imperial College, London, London, London, United Kingdom, 2 Division of Anaesthesia, Cambridge University, Cambridge, Cambridgeshire, United Kingdom, 3 Wolfson Brain Imaging Centre, Cambridge University, Cambridge, Cambridgeshire, United Kingdom, 4 Academic Department of Neurosurgery, Cambridge University, Cambridgeshire, United Kingdom, 5 Department of Computing, Imperial College, London, London, United Kingdom

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. It is clear that much of the sequelae are not just a direct consequence of the acute event represent a dynamic process with changes continuing to occur months to years after the precipitating injury. In this study, longitudinal changes in brain structures known to be important after TBI are presented. The differential effects of volume change are consistent with progressive but selective damaging effects of TBI indicating that individual regions have different vulnerabilities to the effects of injury.

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