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Abstract #3385

MRI detection of pial and subpial abnormalities in the multiple sclerosis spinal cord

Hugh Kearney 1 , Marios C Yiannakas 1 , Rebecca S Samson 1 , Claudia A.M. Wheeler-Kingshott 1 , Olga Ciccarelli 1,2 , and David H. Miller 1,2

1 NMR Research Unit, UCL Institute of Neurology, London, United Kingdom, 2 NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom

Meningeal inflammation has been proposed to cause subjacent parenchymal demyelination in multiple sclerosis ( MS). We therefore investigated the outermost region of the spinal cord containing pia mater and subpial tissue using magnetisation transfer (MT) imaging. In healthy controls, MTR was higher in the outer spinal cord compared to cord white matter, which may reflect an effect of collagen in the spinal cord pia mater. In MS we found a decrease in MTR in this region, which occurred early in the disease course, prior to significant cord atrophy.

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