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Abstract #3383

High-resolution brain imaging in mice with acute and chronic experimental autoimmune encephalomyelitis

Thomas W. Johnson 1 , Nabeela Nathoo 1 , Ying Wu 1 , James A. Rogers 2 , and Jeff F. Dunn 1,3

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, 3 Experimental Imaging Centre, Calgary, Alberta, Canada

High-resolution MRI of mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, was performed using a cryogenically-cooled RF coil. Gross anatomical differences were found in the peak mice, where cerebellar cross-sectional area and dorso-lateral distance were increased. Long-term EAE mice had sizes intermediate between controls and peak-EAE mice. In addition, a novel anoxic sacrifice method of increasing blood vessel contrast was used. A trend of increased blood vessel size was seen in some peak EAE mice, indicating a neuroinflammatory cause. These data show the potential for using high resolution MR and our novel sacrifice method for looking at changes in gross anatomy and blood vessels in mouse brain.

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