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Abstract #3381

Total sodium quantification of the cervical cord in multiple sclerosis

Bhavana Shantilal Solanky 1 , Frank Riemer 1 , Xavier Golay 2 , Olga Ciccarelli 2 , and Claudia AM Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

A careful balance of intra- and extracellular sodium exists in healthy tissue. In multiple sclerosis (MS) sodium imbalances in brain lesions, as well as in normal appearing white matter have been reported. It is thought that this could be due to increased extracellular space, and/or an increased intracellular sodium accumulation. The low SNR of sodium-MRI and the small size of the spinal cord has made quantification in spinal cord challenging. Here we have quantified spinal cord sodium in MS patients for the first time using the recently developed 23 Na-MRS FUSS ISIS sequence.

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