Meeting Banner
Abstract #3375

Imaging the Cortical Myelination Pattern and Its Correlation with Clinical Disability in Multiple Sclerosis

Katherine L Pogrebniak 1,2 , Ziad S Saad 3 , Daniel S Reich 1 , and Govind Nair 1

1 NINDS, National Institutes of Health, Bethesda, MD, United States, 2 Princeton University, Princeton, NJ, United States, 3 NIMH, National Institutes of Health, Bethesda, MD, United States

Cortical myelin is extensively lost in advanced MS and and is thought to be a major cause of disability. Several studies have characterized myelin content of the cortical gray matter using optimized T1-weighted MPRAGE and ratio of T1- over T2-weighted images. In this study of 5 healthy volunteers and 11 MS patients, T1/T2 signal trended to be lower in the cortical ribbon of MS cases vs. healthy volunteers, and this signal change correlated with clinical measures of disability including time required to complete a 9-hole peg test. The technique shows potential as a quantitative marker for cortical demyelination.

This abstract and the presentation materials are available to members only; a login is required.

Join Here