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Abstract #3367

Parametric response maps of perfusion MRI may identify recurrent glioblastomas responsive to bevacizumab and irinotecan

Domenico Aquino 1 , Anna Luisa Di Stefano 2 , Alessandro Scotti 1 , Lucia Cuppini 1 , Elena Anghileri 3 , Gaetano Finocchiaro 3 , Maria Grazia Bruzzone 1 , and Marica Eoli 3

1 Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, 2 General Neurology, IRCCS Istituto Neurologico Nazionale C.Mondino, Pavia, Italy, 3 Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

Perfusion weighted imaging may be useful in the early assessment of response to angiogenesis inhibitors. Aim of this work is to compare Parametric Response Maps with the Region Of Interest approach in the analysis of tumor changes induced by bevacizumab and irinotecan in 42 recurrent glioblastomas, and to evaluate if changes in tumor CBV measured by perfusion MRI may predict clinical outcome. An increased CBV (> 18%) in PRM after 8 weeks of treatment was associated with increased PFS and OS. The presence of two non-contiguous lesions and multifocal disease at baseline were independent predictors of shorter PFS and OS.

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