Abstract #3355
Diffusion kurtosis imaging in differentiation among grade I-II, grade III and grade IV gliomas
Aram Tonoyan 1 , Farida Grinberg 2,3 , Ezequiel Farrher 2 , Igor Pronin 1 , Lyudmila Fadeeva 1 , Valeriy Kornienko 1 , and Nadim Jon Shah 2,3
1
Neuroradiology, Burdenko Neurosurgery
Institute, Moscow, Central Federal District, Russian
Federation,
2
Institute
of Neuroscience and Medicine 4, Medical Imaging
Physics, Forschungszentrum Juelich GmbH, Juelich, North
Rhine-Westphalia, Germany,
3
Faculty
of Medicine, Department of Neurology, RWTH Aachen
University, JARA, Aachen, North Rhine-Westphalia,
Germany
Synopsis Adequate grading of cerebral gliomas prior to
treatment is, among clinical findings such as age and
tumour location, of utmost importance for predicting the
response to treatment and the outcome (the 4th edition
of the WHO CNS tumour classification guidelines).
Invasive histologic examination still remains the
reference standard for obtaining a definitive diagnosis
of brain neoplasms and is required in current oncologic
practice to start adjuvant therapy. Hence, there is a
demand for new non-invasive techniques enabling glioma
grading. In our investigation, we have evaluated the
diagnostic efficacy of diffusion kurtosis MRI to
differentiate between grade I-II, grade III and grade IV
gliomas.
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