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Abstract #3355

Diffusion kurtosis imaging in differentiation among grade I-II, grade III and grade IV gliomas

Aram Tonoyan 1 , Farida Grinberg 2,3 , Ezequiel Farrher 2 , Igor Pronin 1 , Lyudmila Fadeeva 1 , Valeriy Kornienko 1 , and Nadim Jon Shah 2,3

1 Neuroradiology, Burdenko Neurosurgery Institute, Moscow, Central Federal District, Russian Federation, 2 Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Juelich GmbH, Juelich, North Rhine-Westphalia, Germany, 3 Faculty of Medicine, Department of Neurology, RWTH Aachen University, JARA, Aachen, North Rhine-Westphalia, Germany

Synopsis Adequate grading of cerebral gliomas prior to treatment is, among clinical findings such as age and tumour location, of utmost importance for predicting the response to treatment and the outcome (the 4th edition of the WHO CNS tumour classification guidelines). Invasive histologic examination still remains the reference standard for obtaining a definitive diagnosis of brain neoplasms and is required in current oncologic practice to start adjuvant therapy. Hence, there is a demand for new non-invasive techniques enabling glioma grading. In our investigation, we have evaluated the diagnostic efficacy of diffusion kurtosis MRI to differentiate between grade I-II, grade III and grade IV gliomas.

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