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Abstract #3351

31 P MR spectroscopy shows pH-changes in recurrent glioblastomas during antiangiogenic therapy

Ulrich Pilatus 1 , Veronika Vlker 1 , Oliver Bhr 2 , Johannes Rieger 2 , Stella Blasel 1 , Joachim Steinbach 2 , and Elke Hattingen 1

1 Institute of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany, 2 Dr. Senckenbergisches Institut fr Neuroonkologie, Goethe-University Frankfurt, Frankfurt, Germany

31P MR-spectroscopic imaging reveals increased intracellular pH values in recurrent glioblastomas. Antiangiogenic treatment causes a normalization of the pH value, which is reverted upon new tumor progression during the treatment.

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