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Abstract #3348

Glioblastoma Vessels Abnormality Quantification in TOF-MRA

Maddalena Strumia 1,2 , Wilfried Reichardt 1,2 , Irina Mader 3 , Jergen Hennig 2 , and Michael Bock 2

1 Deutsches Konsortium fr translationale Krebsforschung (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, 2 Department of Radiology Medical Physics, University Medical Centre, Freiburg, Germany, 3 Department of Neuroradiologie, University Medical Centre, Freiburg, Germany

The glioblastoma is one of the most malignant and aggressive tumors of the white brain matter, and it expressing vascular endothelial grow factors (VEGF) to initiate and maintain angiogenesis. To assess whether a novel therapeutic drug inhibits neo-angiogenesis, non-invasive imaging methods to study changes of the neo-angiogenic vasculature are urgently needed. In this work we propose new post-processing strategies to quantify the structure of the pathological vessels in glioblastomas using TOF-MRA data. The approach has been applied on 9 glioblastoma patients and showed high discriminability between tumor vessels and normal brain vasculature.

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