Meeting Banner
Abstract #3346

Case Study: 2D L-COSY of Low-Grade Gliomas at 7T

Gaurav Verma 1 , Suyash Mohan 1 , Steven Brem 2 , Michael Albert Thomas 3 , and Harish Poptani 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States, 3 Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States

Two-dimensional (2D) localized correlated spectroscopy (L-COSY) at 7T offers additional spectral separation than is available with conventional sequences or at lower fields. This additional separation could facilitate the unambiguous quantification of ethanolamine, phosphocholine (PC), glycerophosphocholine (GPC), phosphoethanolamine (PE), glycerophosphoethanolamine (GPE) and lactate metabolites whose presence has shown correlation with tumor. 2D L-COSY was acquired in two patients with low-grade gliomas. Resulting spectra showed clearly-defined cross peaks lactate and choline-containing compounds. L-COSY could have clinical utility in detecting biochemical changes in brain tumor and potentially resolving high and low grade tumor and healthy tissue.

This abstract and the presentation materials are available to members only; a login is required.

Join Here