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Abstract #3343

Comparison of gradient- and spin-echo DSC PWI image sequences for determination of contrast agent leakage effects

Nils Daniel Forkert 1 , Heiko Schmiedeskamp 1 , Jalal B. Andre 2 , Reena P. Thomas 3 , Seema Nagpal 3 , Lawrence Recht 3 , Nancy Fischbein 1 , and Roland Bammer 1

1 Department of Radiology, Stanford University, Stanford, CA, United States, 2 Department of Radiology, University of Washington, WA, United States, 3 Department of Neurology and Neurological Sciences, Stanford University, CA, United States

Blood-brain-barrier disruptions may result in contrast agent leakage into the extravascular space, which may hinder a correct determination of perfusion parameters from DSC perfusion-weighted imaging. Considering that brain tumors may not only recruit enlarged, angiogenic vessels, but also smaller microvessels, determining the leakage effect in spin-echo PWI images may lead to additional benefits compared to gradient-echo leakage determination. A first analysis of 10 tumor patient datasets, including a gradient- and spin-echo sequence, revealed very high correlation between the leakage parameters while more pronounced leakage patterns can be found visually in some tumor regions using leakage determination in spin-echo images.

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