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Abstract #3334

Assessing and Reducing the B 1 Dependence of Inhomogeneous Magnetization Transfer

Gopal Varma 1 , Olivier Girard 2 , Novena Rangwala 1 , Guillaume Duhamel 2 , and David C Alsop 1

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2 CRMBM, CNRS 7339, Aix-Marseille Universite, Marseille, France

The application of Inhomogeneous Magnetization Transfer (IHMT) involves off-resonance saturation pulses, and as such may be affected by RF field miscalibration or non-uniformity. A measure of the B 1 dependence from IHMT applied in the brain to a series of volunteers suggests the IHMT contrast saturates at higher powers. These results are used to develop a whole brain IHMT sequence that appears less sensitive to RF field non-uniformity when compared to an existing 3D spoiled gradient-echo IHMT acquisition.

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