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Abstract #3324

Selective Detection of Chemical Exchange Specific R1 by iTIP gagCEST

Wen Ling 1 , Francesca J. Nicholls 1,2 , Tao Jin 1 , Rob Hartman 3 , Nam Vo 3 , Gwendolyn Sowa 3 , James Kang 3 , Michel Modo 1 , and Kyongtae Ty Bae 1

1 Dept. of Radiology, UPMC, Pittsburgh, PA, United States, 2 Dept. of Neuroscience, Kings College London, London, United Kingdom, 3 Dept. of Orthopaedic Surgery, UPMC, Pittsburgh, PA, United States

The implementation iTIP gagCEST on cartilaginous tissue has been simulated, and experimentally conducted on phantoms and a rabbit disc. The results from simulation and phantom have clearly demonstrated that iTIP gagCEST can quantitatively measure chemical exchange specific R1 that linearly increases with PG concentration.

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