Meeting Banner
Abstract #3287

Magnetic susceptibilities of iron rich gray matter nuclei are negatively correlated with various brain functions in healthy adults

Wei Li 1,2 , Christian Langkammer 3 , Katja Petrovic 3 , Reinhold Schmidt 3 , Allen W Song 1,4 , Stefan Ropele 3 , and Chunlei Liu 1,4

1 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 3 Neurology, Medical University of Graz, Graz, Austria, 4 Radiology, Duke University, Durham, NC, United States

In human brain, certain deep gray matter structures, particularly globus pallidus, putamen, caudate nucleus, substantia nigra, red nucleus, and dentate nucleus have especially high iron contents compared to other brain tissues. In this study, we correlated the magnetic susceptibility a surrogate marker of brain iron of these gray matter structures with several clinical measures of brain function in 135 healthy adults aged 40~83 years. We observed significant negative correlations between the scores of motor function, language skills, transit memory, and executive functions with the magnetic susceptibility of one or several of the aforementioned deep brain structures.

This abstract and the presentation materials are available to members only; a login is required.

Join Here