Abstract #3277
Observation of regional variations of conductivity in in-vivo human brain
Jaewook Shin 1 , Min-Oh Kim 1 , Joonsung Lee 1 , Narae Choi 1 , and Dong-Hyun Kim 1
1
Department of Electrical and Electronic
Engineering, Yonsei University, seodaemungu, Seoul,
Korea
Electrical conductivity of human brain tissue reveals
tissue properties such as ion concentration,
micro-structure and temperature. Due to these
relationships between electrical conductivity value and
biological factors, electrical conductivity has a
potential to be a powerful bio-marker. Recently, in
brain area, magnetic resonance electrical property
tomography (MREPT) has been researched for clinical
applications (systematic brain tumor) and biological
characteristics (ion concentration and pH). However, due
to lack of SNR and systemic error on tissue boundary,
there were some restricts to quantify the electrical
conductivity of sub-divisional brain tissue. Therefore,
in this study, we try to observe conductivity values of
sub-divisional brain tissue using weighted polynomial
fitting technique with adaptively generated weighting
factor. The weighting factor was generated using MPRAGE
image that is well-optimized to enhance brain tissue
contrast.
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