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Abstract #3272

Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping in Patients with Chronic Cerebral Ischemia: Comparison with Positron Emission Tomography

Kohsuke Kudo 1,2 , Tian Liu 3 , Jonathan Goodwin 2 , Ikuko Uwano 2 , Fumio Yamashita 2 , Satomi Higuchi 2 , Noriyuki Fujima 1 , Yi Wang 3 , Kuniaki Ogasawara 4 , Akira Ogawa 4 , and Makoto Sasaki 2

1 Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan, 2 Ultra-High Field MRI, Iwate Medical University, Morioka, Iwate, Japan, 3 Radiology, Weill Cornell Medical College, NY, United States, 4 Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan

Oxygen extraction fraction (OEF) represents an important parameter of brain metabolism. The purposes of this study are, to establish OEF measurements using quantitative susceptibility mapping (QSM), and to compare QSM-OEF with the gold standard PET-OEF in patients with unilateral chronic steno-occlusive disease. QSM-OEF value in the affected hemisphere was significantly higher than the contralateral hemisphere. Good correlation of OEF ratio between QSM-OEF and PET-OEF was observed, and the sensitivity and specificity for the detection of increased OEF by QSM was 0.80 and 0.90, respectively.

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