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Abstract #3267

Quantitative Susceptibility Mapping (QSM) in -amyloid-PET-confirmed Alzheimers Disease at 7T

Andreas Schfer 1 , Solveig Tiepolt 2 , Elisabeth Roggenhofer 1 , Robert Trampel 1 , Carsten Stueber 1 , Vilia Zeisig 2 , Udo Grossmann 2 , Thies H. Jochimsen 2 , Osama Sabri 2 , Turner Robert 1 , and Henryk Barthel 2

1 Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department of Nuclear Medicine, University of Leipzig, Germany

In this study we examined 6 patients with beta-amyloid-PET-confirmed Alzheimer disease and 10 healthy controls at 7T. Based on the phase data of a whole brain FLASH sequence with 0.7mm isotropic resolution we calculated the susceptibility maps. Across the group, QSM values in the AD patients were significantly increased compared to healthy controls. The regional analysis showed a significant increase of QSM values in regions typically affected in AD. This more paramagnetic behavior could be due to an increased iron accumulation in brain regions in Alzheimer disease, which may coincide already with early plaque formation.

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