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Abstract #3173

Investigating white matter microstructural changes during demyelination using GRE phase and R2*

Way Cherng Chen 1,2 , Karla Miller 2 , and Kai-Hsiang Chuang 1

1 Singapore Bioimaging Consortium, Singapore, Singapore, Singapore, 2 FMRIB, University of Oxford, Oxford, Oxon, United Kingdom

The relationship between white matter microstructure and GRE signal phase and magnitude was investigated using a cuprizone mouse model of demyelination. Ex vivo R2* and frequency maps showed high correlations with histological myelin stain intensity. Geometric WM modeling suggested that the GRE signal is not only sensitive to the bulk amount of myelin but also the spatial distribution of myelin within WM.

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