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Abstract #3149

The exchange pathways of NOE-CEST as revealed by NMR study

Haifeng Zeng 1,2 , Nirbhay N. Yadav 1,2 , Xiang Xu 1,2 , Kannie W.Y. Chan 1,2 , Guanshu Liu 1,2 , Michael T. McMahon 1,2 , Peter C.M. van Zijl 1,2 , and Jiadi Xu 1,2

1 Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States, 2 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Amide Proton Transfer (APT) and relayed NOE CEST (rNOE-CEST) images of endogenous mobile protein in vivo can be used to detect pH changes as well as tumors. However, the precise mechanisms underlying the magnetization transfer contributions among water, amide protons and aliphatic protons in mobile proteins is still under debate. Using a series of NMR experiments on egg white, we confirmed that the magnetization transfer from water to aliphatic protons is relayed through amide protons.

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