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Abstract #3137

On the Lorentzian versus Gaussian Character of Time Domain Spin Echo Signals Sampled via Gradient Echoes: Implications for Iron Deposition Analyses

Robert V. Mulkern 1 , Mukund Balasubramanian 1 , and Dimitrios Mitsouras 2

1 Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, United States, 2 Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, United States

Previous MRI studies of brain iron deposition have estimated R2 and R2* (or R2') simultaneously from multiple gradient echo sampling of either a single spin echo or a free induction decay and the left side of a spin echo. These studies have, explicitly or implicitly, assumed Lorentzian frequency distributions for the water resonance. Here, we demonstrate that Gaussian frequency distributions, which have a markedly different time domain response, provide a better fit to signals from brain tissue, leading to a more accurate characterization of both the reversible and the irreversible transverse relaxation processes in these tissues.

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