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Abstract #3113

Self-Regulation of the Thalamus with Real-Time fMRI Neurofeedback Enhances Correlation of Thalamic BOLD Activity and EEG Alpha Rhythm

Vadim Zotev 1 , Kymberly D Young 1 , Raquel Phillips 1 , Han Yuan 1 , Masaya Misaki 1 , and Jerzy Bodurka 1,2

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have performed the first study utilizing real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG to elucidate correlations between BOLD activity of the thalamus and posterior EEG alpha rhythm. Ten healthy participants learned to self-regulate fMRI activity of the anterior and mediodorsal nuclei of the thalamus using rtfMRI-nf during a task involving retrieval of happy autobiographical memories. We observed a significant enhancement in temporal correlation between thalamic BOLD activity and EEG alpha rhythm during the rtfMRI-nf training. Our results suggest that rtfMRI-nf with simultaneous EEG is a powerful tool for studying relationships between electrophysiology and hemodynamics of the human brain.

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