Investigating the spatiotemporal characteristics of the BOLD and the non-BOLD response across cortical layers in awake marmosets
Cecil Chern-Chyi Yen 1 , Daniel Papoti 1 , and Afonso C. Silva 1
CMU/LFMI/NINDS, National Institues of
Health, Bethesda, Maryland, United States
The spatiotemporal characteristic of the BOLD signal
across cortical layers has not been well understood due
to the neurophysiological effects of general anesthetics
in animal model or the limitations of spatiotemporal
resolution of the human fMRI. To bridge the gap, a
dual-echo EPI sequence with high spatiotemporal
resolution was used to separate the laminar BOLD
response and non-BOLD response in awake marmoset model.
We had shown the spatiotemporal characteristic of the
laminar BOLD response without complications of
anesthesia and non-BOLD contribution.
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