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Abstract #3096

Investigating the spatiotemporal characteristics of the BOLD and the non-BOLD response across cortical layers in awake marmosets

Cecil Chern-Chyi Yen 1 , Daniel Papoti 1 , and Afonso C. Silva 1

1 CMU/LFMI/NINDS, National Institues of Health, Bethesda, Maryland, United States

The spatiotemporal characteristic of the BOLD signal across cortical layers has not been well understood due to the neurophysiological effects of general anesthetics in animal model or the limitations of spatiotemporal resolution of the human fMRI. To bridge the gap, a dual-echo EPI sequence with high spatiotemporal resolution was used to separate the laminar BOLD response and non-BOLD response in awake marmoset model. We had shown the spatiotemporal characteristic of the laminar BOLD response without complications of anesthesia and non-BOLD contribution.

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