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Abstract #3094

Folded cortical orientation influences the amplitude of BOLD-fMRI: evidence from simulations and experimental data

Louis Gagnon 1,2 , Sava Sakadzic 1 , Frederic Lesage 2 , Joseph J Musacchia 1 , Joel Lefebvre 2 , Qianqian Fang 1 , Meryem A Yucel 1 , Karleyton C Evans 1 , Emiri T Mandeville 1 , Julien Cohen-Adad 2 , Jonathan R Polimeni 1 , Mohammad A Yaseen 1 , Eng H Lo 1 , Douglas Greve 1 , Richard B Buxton 3 , Anders Dale 3 , Anna Devor 3 , and David A Boas 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachussetts General Hospital, Charlestown, MA, United States, 2 Department of Electrical Engineering, Ecole Polytechnique de Montreal, Montreal, QC, Canada, 3 Department of Radiology and Neuroscience, UCSD, LaJolla, CA, United States

We modeled the BOLD response using a set of in vivo vascular measurements obtained with oxygen-sensitive two-photon microscopy. Our model predicted that the folded cortical orientation relative to the main magnetic field can affect the amplitude of the BOLD response by up to 40%. Experimental BOLD measurements during a hypercapnic challenge confirmed this hypothesis. We proposed a method to correct for this confounding effect.

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