Abstract #3090
The differential progression of functional and structural connectivity in a mouse model of demyelination and remyelination
Yi-Ching Lynn Ho 1 , Way Cherng Chen 1 , Hui Chien Tay 1 , Fatima Nasrallah 1 , and Kai-Hsiang Chuang 1
1
Singapore Bioimaging Consortium, Agency for
Science, Technology & Research (A*STAR), Singapore,
Singapore
The increasing use of resting-state fMRI to study brain
development and disease progression raises the question
of how functional connectivity changes in response to
alterations in structural connectivity. Using the
cuprizone mouse model of reversible demyelination, we
tracked the relationship of S1 functional connectivity
to corpus callosum myelination, which was assessed with
histology. Results showed different temporal progression
of the impairment and the recovery of structural and
functional connectivity.
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